РефератыИностранный языкPrProzac Essay Research Paper AbstractAt first it

Prozac Essay Research Paper AbstractAt first it

Prozac Essay, Research Paper


Abstract


At first it was the cure all people were looking for. Then it became the drug they


were afraid to take. Somewhere between these two extremes lies the truth about the drug


Flouxetine, better known as Prozac, the most widely prescribed drug on the globe. It is


mainly prescribed to patients suffering from clinical depression. It was first brought to the


market in 1988 by the pharmaceutical giant Eli Lilly co. Even though it was originally


prescribed for depression, it has been prescribed for everything from eating disorders to


insomnia. It was first considered the wonder drug of the new decade because of the way


it helped depression patients when no other anti-depressant could and then also found to


help many other personality disorders as well. But now it is frowned upon by many.


Some of the side effects contributed to the growing opposition of Prozac include nausea,


constipation, memory impairment, and excess sweating, just to name a few.


What is depression?


Depression can result from a physical disease, a mental illness, or it can be a


recurring reaction of the body. According to the National Institute of Mental Health,


major depressive illnesses are often the result of imbalances in neurotransmitters in the


brain. It is these critical chemicals that send messages between nerve fibers and control


mood (Creamer, 3). Older anti-depressants worked on three different neurotransmitters,


serotonin, norepinepherine, and dopamine. However, it has been found that serotonin is


the specific chemical in the brain that controls moods. It?s job is to carry an impulse from


one nerve fiber to the next. Serotonin is released by the nerve into the space between


nerve fibers, carries the impulse to the next one, and is then reabsorbed by the first. when


it is reabsorbed to quickly, a person feels depressed (6). ?Clinical depression? includes at


least five of the following nine symptoms:


1. Feelings of sadness or irritability.


2. Loss of interest or pleasure in activities once enjoyed.


3. Changes in weight or appetite.


4. Changes in sleeping pattern.


5. Feeling Guilty, hopeless or worthless.


6. Inability to concentrate, remember things, or makes decisions.


7. Fatigue or loss of energy.


8. Restlessness or decreased activity noticed by others.


9. Thoughts of suicide or death.


Dr. Brian K. Martin, President of the Mental Health Association of Hawaii, recommends


that anyone who has suffered five or more of these symptoms for two weeks or longer see


a doctor (7). Nationally, the Mental Health Association estimates that only one-third of


those suffering from depression actually seek help. Most are restrained, according to the


association, ?by fear, lack of knowledge, misinformation, and stigma.? Depression is also


the leading cause of suicide. It is estimated that 15 percent of seriously depressed people


take their own lives (7).


The cons of Prozac


Historically, the use of drugs as fixers of the world?s private ills has run into


serious, if unanticipated, snags. At the turn of the century, the medical community


thought that Cocaine was a completely appropriate, nonaddictive drug, and widely


prescribed it. In the 1950s and ?60s, first barbiturates and then amphetimines were


recommended for various psychological ailments. we now know that each of these drugs


came with significant risks. So what yet-to-be-imparted knowledge may cause science,


once again, to admit sheepishly that the exuberance over Prozac was somewhat


premature, if not wholly overblown?


Possibly, the biggest argument against this drug is merely the fact that it is


prescribed for just about anything. It is estimated that it brought in over 1 billion dollars


last year to Eli Lilly, the pharmaceutical company that brought us this wonder drug about


ten years ago. It is prescribed for everything from eating disorders to panic to helping


with premenstrual syndrome (PMS). David Dolan, Clinical director of one of the


psychiatric programs at Jefferson Hospital in Jeffersonville Ky., agrees with many that


Prozac is way oversold as a cure-all when it first hit the market.


?All of a sudden, Prozac was the medication for everything, then all of a sudden it


was anything but. Almost overnight, a new phenomenon hit Louisville: Prozac panic.


Instead of asking for, people were afraid to take it? (Aprile, 2). The change occurred in


the weeks following Joseph Wesbecker?s rampage, where he fatally shot eight people and


injured 12, only to finally kill himself. After the shooting, lab tests revealed therapeutic


levels of Prozac in his blood. Three other antidepressants and two other prescription


drugs were also found in his blood in tiny amounts. Wesbecker?s medical charts indicated


that his psychiatrist thought Prozac may have been contributing to his worsening


condition. At that time, Jefferson County Coroner Richard Greathouse rose speculation


about Prozac?s possible link to Wesbecker?s violent behavior. No connection was ever


established, although the inquest jury later ruled that side effects from various drugs ?may


have been a contributing factor? (2).


Researchers from Harvard Medical school issued a sort of warning about Prozac in


an issue of the American Journal of Psychiatry. In a case study report of six depressed


patients with complicated psychiatric histories, researchers from the school?s psychiatry


department describe what they call a ?surprising? and unusual side effect of taking Prozac.


?Persistent obsessive and violent suicidal thoughts? were experienced in patients not


having those thoughts prior to taking the prescription. Though they admit much further


study is needed to determine whether this is a ?widespread or valid concern,? they urge


other doctors to ask about suicidal thoughts in patients who the study suggests may be at


risk, including those who develop intense fatigue, restlessness or hypersomnia while taking


Prozac (4).


In February, 1990, Dr. Martin Teicher, a psychiatrist at the highly regarded


McLean Hospital in Belmont, Mass., and two of his colleagues reported that six depressed


patients began to have suicidal thoughts after using Prozac. Writing in The American


Journal of Psychiatry, Teicher said that when they began taking the drug, none of the six


patients were suicidal and all were ?hopeful and optimistic? about the treatment. After


that, a sudden flow of reports told of violence and suicide among Prozac users. And the


drug acquired a tenacious enemy in the Los Angeles-based Citizens Commission on


Human Rights, which has ties to the Church of Scientology, a movement that, amongst


other things, opposes some aspects of psychiatry. The Scientologists claim that by Sept.


16, 1993, no fewer than 1,089 suicides had been recorded among patients taking the


capsule. If that figure is correct, than it works out to be about .01 percent of the 11


million people who have used the drug (Nichols, 3)


Dr. Lorne Brandes, A Winnipeg cancer researcher, claims to have evidence that Prozac


may promote the growth of cancerous tumors. ?I?m very concerned about Prozac,? says


Brandes, who reported in 1992 that rats and mice with artificially induced cancer showed


an increased rate of tumor growth when they were given Prozac and another


antidepressant not mentioned. Brandes?s findings alarmed some cancer researchers and


prompted federal scientists to launch similar studies (Nichols, 1).


Although Prozac has fewer side-effects that earlier an

tidepressants, it does have


some. Users may experience nausea, nervousness and insomnia, and their sex lives may


suffer some: a U.S. study, published in The Journal of Clinical Psychiatry, found that


among 160 patients on Prozac, 54 reported that sexual desires or responses diminished


after they began taking the drug (1).


Sidney Wolfe, director of the Public Citizen Health Research Group, a Washington


based consumer advocacy organization, compares Prozac to Valium, the popular


tranquilizer that was on the market for more than 10 years before doctors discovered its


highly addictive properties during the mid-1970s. ?Prozac has become the Valium of the


1990s,? declares Wolfe (Nichols, 4)


Finally, one of the weaker arguments against Prozac is that it is very expensive,


with a cost of about fifty dollars for a month?s supply. It costs more than older drugs now


available as generics, like amitriptyline (Aprile, 3).


The Pros of Prozac


In defense of Prozac, Eli Lilly officials say that it is one of the most thoroughly


tested medications in history: more than 32,000 people took part in Prozac?s clinical trials,


and scientist have conducted at least 3,000 separate studies. ?Nothing alarming has shown


up,? says Cameron Battley, corporate affairs manager for Lilly. He also insist that, despite


reports of the drug being used to treat people who do not really need an antidepressant,


?there is absolutely no indication of any inappropriate use of Prozac? (Nichols, 2).


When Eli Lilly and Co. won Federal Food and Drug Administration(FDA)


approval for Prozac in December of 1987, it was specifically for the treatment of


depression. But there?s been plenty of publicity about the drug?s potential for helping


people with a host of other maladies, ranging from obesity and bulimia, to panic attacks,


alcoholism, PMS, smoking addictions and obsessive-compulsive disorders (Aprile, 1).


Although Jefferson County Coroner Richard Greathouse was quoted earlier to


suspect Prozac in Joseph Wesbecker?s violent rage, he says, ?I want to go on record


saying I am not indicting this drug.? He says he only raised questions; he never drew


conclusions. ?I personally am not afraid of the drug,? he said. In fact, Greathouse


prescribes it in his own private pediatrics practice. He also goes on to say that his


investigation–which included a study of ?a complete FDA file on Prozac about


yea-deep?–convinced him that there was no proven link between the use of the drug and


violent behavior. ?The whole problem is, would they have done it anyway? Would they


have taken a violent, destructive path regardless? That?s the $64,000 question? (Aprile,


2).


Drugs to fight depression have existed for more than thirty years. The first type


was Tricyclic antidepressants, like Elavil. Those were then followed by MAO inhibitors,


like Parnate or Nardil. Both of these types of drugs relieve depression by acting on


substances in the brain that regulate emotional highs and lows. Prozac is considered a


breakthrough because of the ?selective? way it works. Unlike tricyclics, Prozac rarely


causes the adverse effects typical of Tricyclic antidepressants–dry mouth, confusion,


constipation, dizziness, blurred vision, heart problems, and weight gain. Also, it is easy to


take a 20-milligram pill, once a day, which is a standard beginning regimen, and tends to


lift depression relatively quickly and appears difficult to overdose (3).


According to Edward West, director of corporate communications for Lilly, the


company knows of fewer than ten physical assaults and two murder-suicides committed by


anyone on the medication. These do however, include Wesbecker?s rampage. West told a


Courier-Journal reporter that the firm sees ?no trend that suggests a casual relationship


between Prozac and assaultive type of behavior.? The FDA agrees. Eva Kemper, a


spokeswoman for the federal agency, said the number of Prozac-related homicides and


violent incidents is ?not-high? for an antidepressant as popular as it is (4).


In the 1992 British Journal of Psychiatry, authors, A.C. Power and P.J. Cowen


analyzed a broad number of studies involving Prozac and suicide. They concluded that


controlled trials do not show Prozac leads to a worsening of suicidal ideas. Eli Lilly?s


spokeswoman, Kelly Weston, says that the drug?s suicidality was repeatedly tested in


clinical trials and results actually showed that patients on Prozac experience suicidality less


frequently than patients on a placebo or another antidepressant. The same thing has been


shown in terms of violent behaviors. Antidepressants like Prozac seem to have a


protective effect. The tendency toward violence will actually decrease.


Dr. James Brookes, a Toronto general practitioner, says that there is generous


praise from doctors and patients for an antidepressant that has made it easier to treat a


debilitating illness. The side-effects of older antidepressants–including a parched mouth,


difficulty in urinating and feeling of psychological detachment– made them hard to take.


?There were serious problems involved in getting patients to tolerate those drugs in


therapeutic doses,? says Brooks, ?but, with Prozac, you don?t have this. I?m really


pleased with Prozac.? ( Nichols, 2)


Many patients are equally enthusiastic. William Pringle, Vancouver special events


organizer, was flattened by a major depression. His doctor put him on Prozac. ?I fell into


a dark pit,? says Pringle. ?Prozac pulled me out and got me relaunched on my life.?


Maria Theresa Spagnuolo of Toronto began taking it in 1989, after three


automobile accidents left her with chronic pain throughout her body. And she also


suffered serious depression. Spagnuolo found that she ?was crying about everything,


spilled milk was a catastrophe. But Prozac gave me energy and changed my outlook so


that I can cope with life. I don?t think I could function without it? (2).


For one Hawaiian business woman, who had a steady diet of antidepressants and


psychotherapy off and on for 20 years before Prozac, but never lost her sense of despair,


the past three years with Prozac have been miraculous. ?I felt fabulous not as in `up`, but


as in `my god, I started to be normal,`? she said. ? Now I get sad when there?s reason to


be sad, but I don?t feel hopeless? (Creamer, 1).


In conclusion, the positives of Prozac definitely outweigh the negatives. All


medications will have some side-effects, that is a given. Everything from Aspirin to Advil


to prescription Penicillin have some kind of side effects, but everyone still takes these


medications. Why, because they work. No-one can argue that Prozac is working for


many people, considering that it is the most prescribed drug in the world. But if it is not


right for you, then you need to find what is good for you, not everyone can take every


kind of medicine. Some people have allergies, that?s going to happen. The bottom line is,


it is difficult to argue with clear results.


Works Cited


Aprile, Diane. ?Prozac.? Courier-Journal Feb. 18, 1990


Bihm, Barbara; Wilson, Billie Ann. ?Understanding Fluoxetine (Prozac).? Medsurg


Nursing Feb. 1, 1996


Creamer, Beverly. ?Prozac: Its Effects Still Subject to Debate.? Honolulu Advertiser


May 30, 1993


Mauro, James; Breggin, Peter. ?And Prozac for All…? Psychology Today July 1,1994


Nichols, Mark. ?Questioning Prozac.? Maclean?s May 23, 1994: 36-41


Fluoxetine (Prozac)


fluoxetine (Prozac)


The Pros and Cons of Prozac


Ken Berardis

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